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DNA-encoded libraries (DELs) allow for the rapid and simultaneous screening of hundreds of billions of small molecule compounds against the protein target of interest. DELs are produced from chemical building blocks through a process of split/pool combinatorial chemistry, and each compound in the library is physically linked to a DNA barcode denoting each compound’s structure.

Through a collaboration with HitGen, a premier DEL company with libraries of over 1 trillion compounds, UNC researchers have no-cost access to this technology in exchange for sharing of the resulting intellectual property or may access HitGen through a negotiated fee-for-service arrangement.

To submit targets for consideration and assessment, please use the AdvanTx Portal.